Breathing is a vital function of our existence, which involves inhaling air into our lungs and exhaling it. Through inhalation, we take in Oxygen from the perspective that fuels our bodies; through exhalation, we expel carbon dioxide. Apart from providing Oxygen, breathing can also effectively manage stress and anxiety. We can calm our minds and reduce stress by performing deep breathing exercises. Proper breathing techniques help improve our lung health and increase respiratory capacity.
Whether you move, sleep, or do any activity, breathing is a fundamental and essential bodily function that serves several crucial purposes, with Oxygen being a key component of its significance.
Why breathing and Oxygen are essential:
1.Cellular Respiration: Oxygen is required by cells in the body for cellular respiration. This process occurs in the mitochondria of cells and involves the breakdown of glucose to produce energy in the form of adenosine triphosphate (ATP). Without Oxygen, cells cannot efficiently generate energy, leading to cell dysfunction and potential damage.
However, there are two main types of cellular respiration, aerobic and anaerobic, and they differ in their oxygen requirements:
Aerobic Respiration: It occurs in the presence of Oxygen and involves the complete breakdown of glucose and other organic molecules into carbon dioxide and water.
Aerobic respiration produces a significantly more significant amount of ATP compared to anaerobic respiration.
Anaerobic Respiration: Without sufficient Oxygen, cells can still generate ATP through anaerobic respiration. This process involves the partial breakdown of glucose without using Oxygen and typically produces lactic acid (in humans). While anaerobic respiration allows cells to generate some ATP, it is far less efficient than aerobic respiration. It can lead to the buildup of metabolic byproducts that can be detrimental to the cell if not cleared.
However, prolonged reliance on anaerobic respiration can lead to cell dysfunction and potential damage due to less efficient energy production and the accumulation of metabolic byproducts.
2. Energy Production: As mentioned earlier, Oxygen is vital for producing ATP, which fuels various physiological processes, including muscle contraction, nerve function, and overall metabolism. Adenosine triphosphate (ATP) is often called the "energy currency" of cells because it provides the energy necessary for various physiological processes.
Oxygen plays a central role in the generation of ATP through aerobic respiration. Here's how it works:
a. Glycolysis: The breakdown of glucose begins in the cytoplasm of the cell through glycolysis. In glycolysis, one glucose molecule is converted into two pyruvate molecules. This process doesn't require Oxygen and is the same in aerobic and anaerobic respiration.
b. Krebs Cycle (Citric Acid Cycle): In the presence of Oxygen, the pyruvate molecules produced during glycolysis enter the mitochondria, where they are further broken down in a series of reactions known as the Krebs cycle. This cycle generates electron carriers (NADH and FADH2) and a small amount of ATP.
b.2. Electron Transport Chain (ETC): The electron carriers produced in the Krebs cycle enter the electron transport chain, which is embedded in the inner mitochondrial membrane.
Oxygen is the final electron acceptor in this chain. As electrons pass through the chain, protons (H+ ions) flow across the membrane, creating an electrochemical gradient.
c. ATP Synthesis: The flow of protons back into the mitochondrial matrix through ATP synthase is used to generate ATP. This process, called oxidative phosphorylation, is entirely dependent on Oxygen. Oxygen acts as the "terminal electron acceptor" at the end of the chain, allowing electrons to flow smoothly and maintaining the proton gradient.
3. Brain Function: The brain is one of the most oxygen-dependent organs in the body. It requires a continuous supply of Oxygen to function correctly. Insufficient Oxygen can lead to impaired cognitive function, difficulty concentrating, and even unconsciousness.
Why the brain needs Oxygen
Oxygen Dependency: The brain relies heavily on Oxygen to perform its functions. Even short periods of reduced oxygen supply (hypoxia) can harm brain function.
Unlike other organs that can tolerate brief oxygen deprivation, the brain is susceptible and can suffer damage quickly when oxygen levels drop.
Energy Demands: The brain has high energy demands due to constant activity. It requires substantial ATP for processes like neurotransmitter synthesis, maintaining membrane potentials, and conducting electrical signals between neurons. Adequate Oxygen is essential for the efficient production of ATP through aerobic respiration.
Cognitive Function: Oxygen deprivation can lead to cognitive impairment, even if only partial. Common symptoms of insufficient Oxygen to the brain include difficulty concentrating, memory problems, reduced alertness, and slower reaction times. In severe cases, it can result in confusion and disorientation.
Unconsciousness and Brain Damage: Prolonged oxygen deprivation can lead to loss of consciousness and permanent brain damage if not promptly addressed. When oxygen levels in the brain drop significantly, brain cells (neurons) become more vulnerable to injury and can die, leading to neurological deficits or even coma.
Preventing Brain Injury: Adequate oxygen supply is crucial in medical emergencies such as strokes, heart attacks, or respiratory failure. Promptly restoring Oxygen to the brain in these situations is a top priority to minimize brain damage.
Sleep and Oxygen: Oxygen levels can also impact the quality of sleep. Conditions like sleep apnea, which involve intermittent cessation of breathing during sleep, can lead to disruptions in oxygen supply to the brain, potentially causing daytime fatigue and cognitive problems.
4. Removal of Waste Products: Carbon dioxide (CO2) is produced as a waste product during cellular respiration. Proper breathing allows the body to eliminate this waste gas, preventing its accumulation in the bloodstream. Carbon dioxide buildup can lead to respiratory acidosis, disrupting the body's acid-base balance.
Removal of waste products, specifically carbon dioxide (CO2), through proper breathing is accurate. Reducing CO2 is a vital function of the respiratory system and is essential for maintaining the body's acid-base balance.
Carbon Dioxide Production: Cells produce carbon dioxide (CO2) as a metabolic waste product during cellular respiration. This CO2 results from the breakdown of glucose and other organic molecules for energy in the presence of Oxygen.
Respiratory System: The respiratory system, which includes the lungs and airways, is crucial in eliminating excess CO2 from the body. As part of this process, Oxygen is taken in from the air, and CO2 is expelled from the body through exhalation.
Gas Exchange: In the lungs, Oxygen is exchanged for carbon dioxide through tiny air sacs called alveoli. Red blood cells take oxygen up, while carbon dioxide is released into the air in the lungs.
pH Regulation: Carbon dioxide is not just a waste product but also a critical regulator of the body's pH (acid-base balance). When CO2 levels in the bloodstream rise, it combines with water to form carbonic acid (H2CO3). This reaction helps maintain the blood's pH within a narrow, slightly alkaline range.
Respiratory Acidosis: If there is a buildup of carbon dioxide in the bloodstream due to inefficient removal (for example, in cases of respiratory problems or hypoventilation), it can lead to respiratory acidosis. In respiratory acidosis, the blood becomes more acidic, disrupting normal bodily functions and leading to symptoms such as confusion, shortness of breath, and, in severe cases, coma.
Proper Breathing: Adequate and efficient breathing ensures that carbon dioxide is continually eliminated from the body, helping to maintain the body's pH balance within the normal range. The body can adjust the Breathing rate and depth to regulate CO2 levels as needed.
5. Supports Aerobic Exercise: During physical activity, muscles require more Oxygen to meet increased energy demands. Efficient breathing helps deliver Oxygen to muscles, enabling them to perform aerobic exercise (exercise that requires Oxygen) more effectively.
Efficient breathing is critical in delivering oxygen to muscles and supporting increased energy demands during physical activity.
Oxygen Demand: During aerobic exercise, such as running, cycling, swimming, or brisk walking, the body's energy demands increase significantly. Muscles require a continuous supply of Oxygen to fuel the process of aerobic respiration, which is essential for sustained physical activity.
Increased Respiratory Rate: To meet the elevated oxygen demand, the respiratory system responds by increasing the rate and depth of breathing. This allows the lungs to take in more Oxygen from the air and deliver it to the bloodstream for distribution to active muscles.
Efficient Oxygen Exchange: Efficient breathing ensures that the exchange of gases (Oxygen and carbon dioxide) in the lungs occurs optimally. Oxygen is removed from inhaled air, while carbon dioxide, a metabolic waste product, is expelled during exhalation.
Muscle Efficiency: Adequate oxygen supply to muscles enables them to produce ATP through aerobic respiration, which is highly efficient and sustainable for prolonged exercise. This results in improved muscle performance, endurance, and reduced fatigue.
Delaying Fatigue: Efficient breathing helps delay the onset of muscle fatigue during aerobic exercise. When the oxygen supply to muscles is sufficient, they can continue to contract and perform efficiently, allowing you to exercise for longer durations.
Recovery: Proper breathing techniques can also aid in post-exercise recovery. Deep, controlled breathing can help reduce post-exercise muscle tension, promote relaxation, and facilitate the removal of metabolic waste products such as lactic acid.
Stress Reduction: Focused, rhythmic breathing techniques, such as those used in yoga or mindfulness, can help reduce stress, improve mental focus, and enhance overall exercise performance.
6. Maintenance of Homeostasis: Oxygen is crucial in maintaining the body's internal balance or homeostasis. It supports the optimal functioning of various cardiovascular and respiratory systems, which work together to deliver oxygen to tissues and remove waste products.
Homeostasis is the body's ability to maintain a stable internal environment despite external changes, and Oxygen plays a pivotal role in this process.
Metabolic Homeostasis: Oxygen is essential for maintaining metabolic homeostasis, which involves balancing physiological processes such as temperature regulation, pH balance, and nutrient metabolism. Proper oxygen levels are crucial for the efficient functioning of metabolic reactions.
Cardiovascular System: Oxygen is transported throughout the body by the cardiovascular system, primarily through the bloodstream. The heart pumps oxygen-rich blood to tissues and organs, ensuring they receive the necessary Oxygen to function optimally. Any disruption in this process can lead to imbalances and health issues.
Respiratory System: The respiratory system, including the lungs and airways, is responsible for exchanging Oxygen and carbon dioxide with the external environment. It works with the cardiovascular system to deliver oxygen to tissues and remove carbon dioxide, thus contributing to pH regulation and maintaining overall homeostasis.
PHBalance: Oxygen is critical to maintaining the body's acid-base balance (pH). Adequate oxygen levels are necessary to prevent respiratory acidosis (caused by excessive carbon dioxide buildup) and maintain blood pH within the narrow, optimal range.
Temperature Regulation: Oxygen is involved in oxidative metabolism, which generates heat. A proper oxygen supply ensures the body can regulate its temperature effectively, preventing overheating or hypothermia.
Nutrient Processing: Oxygen is required to oxidize nutrients, including carbohydrates, fats, and proteins, to produce energy. This energy is vital for maintaining the body's functions and energy balance.
Cellular Function: Every cell in the body requires Oxygen for its metabolic processes. Without sufficient Oxygen, cells may not function properly, leading to a disruption in overall homeostasis.
Response to Stress: Adequate oxygen helps the body respond to stressors more effectively. In situations where the body needs to increase its metabolic activity, such as during exercise or an illness, Oxygen supports these heightened energy demands.
7. Immune System Support: Oxygen is necessary to function immune cells, such as white blood cells, properly. These cells are vital in defending the body against infections and illnesses. Sufficient oxygen levels help ensure that immune responses are effective.
Oxygen is necessary for the proper functioning of immune cells, which play a crucial role in defending the body against infections and illnesses. Here's a more detailed explanation:
Immune Cell Activity: The immune system consists of various immune cells, including white blood cells (leukocytes). These cells identify and combat pathogens, such as bacteria, viruses, and other foreign invaders.
Oxygen-Dependent Processes: Many immune cell activities, including phagocytosis (engulfing and destroying pathogens), the production of antibodies, and the release of signaling molecules called cytokines, require energy. This energy is primarily generated through aerobic respiration, which relies on Oxygen.
Inflammation and Immune Response: Oxygen is essential for inflammation, a critical immune response component. When tissues become infected or injured, immune cells are recruited to the site. Oxygen is required for these immune cells to effectively perform their functions, including producing reactive oxygen species (ROS) that help destroy pathogens.
Tissue Healing: Oxygen is also vital for tissue repair and healing, often necessary after an immune response. Immune cells and other cells involved in tissue repair rely on Oxygen to generate energy and promote tissue regeneration.
Hypoxia and Immune Function: Insufficient oxygen levels in tissues (hypoxia) can impair immune cell function. Hypoxic conditions can hinder the ability of immune cells to move, respond to pathogens, and produce necessary molecules for immune defense. This can lead to weakened immune responses and an increased susceptibility to infections.
Supporting Immune Function: Maintaining adequate oxygen levels in the body through proper breathing and cardiovascular health supports the overall efficiency and effectiveness of the immune system. A good oxygen supply helps ensure immune cells have the energy and resources to combat infections and protect the body.
8. Cell Repair and Growth: Oxygen is essential for cell repair and growth processes. Tissues and organs rely on Oxygen to heal and regenerate, supporting overall health and recovery from injuries.
Oxygen is necessary for the proper functioning of immune cells, which play a crucial role in defending the body against infections and illnesses. Here's a more detailed explanation:
Oxygen is critical in these processes, essential for tissue maintenance, healing, and overall health.
Cellular Repair: Oxygen is crucial for cellular repair mechanisms. When tissues are injured, cells in the affected area need Oxygen to carry out processes such as DNA synthesis, protein production, and membrane repair. Oxygen supports the energy demands of these repair processes.
Wound Healing: Oxygen is necessary for adequately functioning immune cells involved in wound healing. Neutrophils and macrophages, for example, use Oxygen to generate reactive oxygen species (ROS) that help eliminate bacteria and other foreign materials at the injury site. Oxygen also supports fibroblasts, responsible for collagen production and tissue remodeling during wound healing.
Cell Proliferation: Oxygen is required for cell division and proliferation, a fundamental tissue growth and repair process. Adequate oxygen levels support the formation of new cells and tissues, allowing the body to replace damaged or old cells.
Angiogenesis: Oxygen is involved in angiogenesis, forming new blood vessels. During tissue repair and growth, the body must establish a network of blood vessels to deliver nutrients and Oxygen to the growing tissues. Oxygen helps regulate this process.
Muscle Recovery: Oxygen is essential for muscle recovery and growth. After strenuous exercise or physical activity, Oxygen plays a role in repairing muscle fibers and promoting muscle hypertrophy (growth). Sufficient oxygen supply aids in reducing muscle soreness and accelerating recovery.
Bone Health: Oxygen is also essential for bone health and healing. Bone-forming cells called osteoblasts require Oxygen to produce the proteins and minerals needed to strengthen and repair bones.
Organ Regeneration: In organ injury or damage, such as in the liver, Oxygen supports the regenerative capacity of specific tissues and organs. Liver cells, for example, rely on Oxygen to regenerate and restore normal function.
Chronic Wound Healing: In chronic wounds, where oxygen supply may be compromised due to poor circulation, introducing supplemental oxygen therapy can promote healing by providing the necessary Oxygen for repair processes.
9. Detoxification: Oxygen aids in the detoxification process by assisting the liver in breaking down and eliminating toxins from the body. It is an integral component of various enzymatic reactions involved in detoxification pathways.
Oxygen is integral to the body's detoxification mechanisms, especially in the liver, which is crucial in breaking down and eliminating toxins.
Liver Detoxification: The liver is a primary organ responsible for detoxifying harmful substances, including drugs, alcohol, metabolic waste products, and environmental toxins. This process occurs mainly in the hepatocytes (liver cells).
Phase I and Phase II Reactions: Liver detoxification involves two main phases: Phase I and Phase II reactions.
Phase I: During Phase I, various enzymes, such as cytochrome P450 enzymes, chemically modify toxins to make them more water-soluble. This modification can sometimes generate free radicals and other reactive intermediates, which need to be neutralized.
Phase II: In Phase II, conjugation reactions occur, where these modified toxins are combined with other molecules (e.g., glutathione, sulfate, glucuronic acid) to make them even more water-soluble and less toxic. These conjugated toxins can then be excreted from the body.
Role of Oxygen: Oxygen is critical in Phase I and II detoxification reactions. In Phase I, Oxygen is essential for the cytochrome P450 enzymes to function effectively and convert toxins into more easily processed forms. Without Oxygen, these reactions cannot proceed efficiently.
Antioxidant Systems: While Oxygen is necessary for detoxification, it can also generate free radicals during Phase I reactions. To counteract the potential oxidative stress caused by free radicals, the body relies on antioxidant systems, such as glutathione, to neutralize them.
Detoxification Enzymes: Many detoxification enzymes involved in Phase II reactions are oxygen-dependent. These enzymes require Oxygen to catalyze the conjugation of toxins with various molecules, making them suitable for excretion.
Overall Detoxification: Proper oxygen supply to the liver ensures that the detoxification pathways can function optimally. Adequate oxygen levels help the liver efficiently process and eliminate toxins from the body, promoting overall health and reducing the risk of toxic buildup.
Respiratory Elimination: Once toxins are detoxified and conjugated in the liver, they are often excreted from the body via the respiratory system. This underscores the importance of Oxygen in the final elimination of these substances.
10. Vital Signs Indicator: Breathing and oxygen levels often indicate a person's overall health. Medical professionals monitor breathing rates, oxygen saturation levels, and other respiratory parameters to assess a patient's well-being and identify potential health issues.
Monitoring these respiratory parameters is a fundamental aspect of assessing a person's overall health, and it provides valuable information to medical professionals for diagnosing and managing various health conditions. Here's a more detailed explanation:
Breathing Rate (Respiratory Rate): The number of breaths a person takes per minute is the respiratory rate. The average adult respiratory rate typically ranges from 12 to 20 breaths per minute at rest. Abnormalities in breathing rate, such as rapid or shallow breathing, may indicate various medical conditions, including respiratory distress, infections, or metabolic disorders.
Oxygen Saturation (SpO2): Oxygen saturation measures the percentage of hemoglobin in the blood bound to Oxygen. It is typically measured using a pulse oximeter, a non-invasive device that clips onto a person's fingertip. Normal oxygen saturation levels are typically between 95% and 100%. Lower oxygen saturation levels may suggest hypoxemia (low blood oxygen) and indicate lung disease, heart problems, or other medical issues.
Respiratory Pattern: Besides the rate, the breathing pattern is essential. Irregular breathing patterns, such as Cheyne-Stokes or Kussmaul breathing, can provide insights into the underlying medical condition. For example, Cheyne-Stokes breathing is often seen in conditions like heart failure and brain injuries.
Breathing Sounds: Listening to breathing sounds, such as wheezing, crackles, or stridor, can help diagnose respiratory issues like asthma, pneumonia, or airway obstructions.
Pulse: The pulse rate and rhythm are closely related to respiratory function. A rapid or irregular pulse may indicate respiratory distress or a cardiovascular issue.
Physical Examination: Medical professionals may assess the patient's overall appearance, including signs of respiratory distress like increased effort in breathing, use of accessory muscles, or cyanosis (bluish discoloration of the skin or lips) due to low oxygen levels.
Diagnostic Tools: Additional diagnostic tools, such as chest X-rays, arterial blood gas (ABG) tests, or pulmonary function tests, may further evaluate respiratory health and identify specific conditions.
Treatment Monitoring: Monitoring respiratory parameters is crucial during treatment and hospital care. It helps healthcare providers assess the effectiveness of interventions and make necessary adjustments.
Breathing and Oxygen intake are critical for various physiological processes that support overall health and well-being. Adequate oxygen supply enables efficient energy production, cognitive function, waste removal, immune responses, and proper functioning of vital organs and systems.
Lets breath and enhance our wellness and performance .
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References
Mitchell, B., Siriwardhana, C., Kohorn, L., Chew, G., Bowler, S., Kallianpur, K., Chow, D., Ndhlovu, L., Gerschenson, M., & Shikuma, C. (2020). Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation. PLoS One, 15(4), e0231761.
Dunn, J-Oc, et al. "Physiology of Oxygen Transport." BJA Education, 2016, https://doi.org/10.1093/bjaed/mkw012.
Vipassana Meditation: A Journey to Inner Peace - Aleenta Retreat Chiang Mai. https://www.aleenta.com/blog/vipassana-meditation-a-journey-to-inner-peace/
Every Breath You Take: Air Pollution and Exercise – iRunFar. https://www.irunfar.com/every-breath-you-take-air-pollution-and-exercise
What is SpO2? – Pulse Oximetry – Oxygen Saturation – Santa Medical. https://santamedical.com/blogs/news/what-is-spo2-pulse-oximetry-oxygen-saturation
Acknowledgment to the Reviewers of Oxygen in 2022. (2023, January 18). Oxygen, 3(1), 32–33. https://doi.org/10.3390/oxygen3010003
Hocke, K. (2023, June 27). Oxygen in the Earth System. Oxygen, 3(3), 287–299. https://doi.org/10.3390/oxygen3030019
Jávega, B., Herrera, G., Martínez-Romero, A., & O’Connor, J. E. (2023, June 5). Flow Cytometry of Oxygen and Oxygen-Related Cellular Stress. Oxygen, 3(2), 222–255. https://doi.org/10.3390/oxygen3020016
Björn, L. O. (2022, August 26). Photosynthetic Production of Molecular Oxygen by Water Oxidation. Oxygen, 2(3), 337–347. https://doi.org/10.3390/oxygen2030024
Boehm, F., Edge, R., & Truscott, T. G. (2023, August 3). Photochemical and Photophysical Properties of Carotenoids and Reactive Oxygen Species: Contradictions Relating to Skin and Vision. Oxygen, 3(3), 322–335. https://doi.org/10.3390/oxygen3030021
Edge, R., & Truscott, T. G. (2021, October 27). The Reactive Oxygen Species Singlet Oxygen, Hydroxy Radicals, and the Superoxide Radical Anion—Examples of Their Roles in Biology and Medicine. Oxygen, 1(2), 77–95. https://doi.org/10.3390/oxygen1020009
Gupta, M. (2019). Hyperbaric oxygen therapy: Trends at Prana Hyperbaric Oxygen Therapy Centre Mumbai, India. New Indian Journal of Surgery, 10(1), 41–48. https://doi.org/10.21088/nijs.0976.4747.10119.7
Phantom of the Oxygraph: Artifactual Oxygen Consumption Resulting from the Evolution of Nitrogen or Other Low Solubility Non-Oxygen Gas. (2023, June 5). Reactive Oxygen Species. https://doi.org/10.20455/ros.2023.c801
Oxygen delivery and oxygen consumption. (1990, April). Burns, 16(2), 153–154. https://doi.org/10.1016/0305-4179(90)90185-y
Lim, H. S. (2016, August). Cardiogenic Shock: Failure of Oxygen Delivery and Oxygen Utilization. Clinical Cardiology, 39(8), 477–483. https://doi.org/10.1002/clc.22564
Tukang, F. M., Santoso, S. D. R. P., & Paju, W. (2023, July 31). Penerapan Intervensi Berdasarkan Evidence Based Nursing: Breathing Exercise (PLB, Deep Breathing, Diaphragm Breathing) terhadap Sesak pada Pasien Pneumonia. Jurnal Keperawatan Sumba (JKS), 2(1), 1–10. https://doi.org/10.31965/jks.v2i1.1286
Impact of Impaired Nasal Breathing on Sleep-Disordered Breathing. (2003). Sleep and Breathing, 07(2), 063–076. https://doi.org/10.1055/s-2003-40664
Breathing Pattern, Work of Breathing and Gas Exchange in Patients With ARDS During the Spontaneous Breathing Test. (2019, December 24). Case Medical Research. https://doi.org/10.31525/ct1-nct04209270
Drummond, G. (2010, September 15). Like breathing out and breathing in . . .. The Journal of Physiology, 588(18), 3345–3345. https://doi.org/10.1113/jphysiol.2010.196501
Relation of Tea Likeliness and Normal Breathing Rate. (2019, February 6). Journal of Clinical & Experimental Immunology, 4(1). https://doi.org/10.33140/jcei.04.01.15
Homma, I., & Masaoka, Y. (2008, August 14). Breathing rhythms and emotions. Experimental Physiology, 93(9), 1011–1021. https://doi.org/10.1113/expphysiol.2008.042424
Stanford, W., Jeffrey, G., & Rooholamini, M. (1988, July). Effects of Awake Tidal Breathing, Swallowing, Nasal Breathing, Oral Breathing and the Müller and Valsalva Maneuvers on the Dimensions of the Upper Airway. Chest, 94(1), 149–154. https://doi.org/10.1378/chest.94.1.149
Kareva, Y. Y., & Eremina, S. S. (2022). BREATHING EXERCISES. THE USE OF FRACTIONAL BREATHING MECHANISMS. OlymPlus. Гуманитарная Версия, 1, 63–66. https://doi.org/10.46554/olymplus.2022.1(14).pp.63
Coppola, M. (2000, July). Cardiovascular Disease and Sleep-Disordered Breathing: The Bridge to the Mainland. Sleep and Breathing, 4(3), 101–101. https://doi.org/10.1007/s11325-000-0101-2
Yokogawa, M., Kurebayashi, T., Soma, K., Miaki, H., & Nakagawa, T. (2019, September 16). Investigation into Deep Breathing through Measurement of Ventilatory Parameters and Observation of Breathing Patterns. Journal of Visualized Experiments, 151. https://doi.org/10.3791/60062
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